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Metal‐Free Regioselective Dual C‐H Functionalization in a Cascade Fashion: Access to Isocryptolepine Alkaloid Analogues
Author(s) -
Murugan Arumugavel,
Vidyacharan Shinde,
Ghosh Ruma,
Sharada Duddu S.
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700263
Subject(s) - regioselectivity , surface modification , indazole , benzylamine , combinatorial chemistry , chemistry , cascade , cascade reaction , substrate (aquarium) , organic chemistry , catalysis , oceanography , chromatography , geology
Abstract A metal‐free regioselective approach to annulated indazoles is presented via dual C−H functionalization of indazole and benzylamine in a cascade fashion. The salient features of the present protocol are regioselective C3‐functionalization, one‐pot synthesis of annulated scaffolds, metal‐free, peroxide‐free, operationally simple and wide substrate scope.