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Copper‐Catalyzed Remote C‐H Sulfonylation of 8‐Aminoquinoline Amides with Arylsulfonyl Hydrazides
Author(s) -
Chen Guoshu,
Zhang Xuejian,
Zeng Zihui,
Peng Wanying,
Liang Qiongzhi,
Liu Jidan
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700235
Subject(s) - catalysis , copper , aryl , chemistry , combinatorial chemistry , organic chemistry , alkyl
An efficient copper‐catalyzed remote C‐5 sulfonylation of 8‐aminoquinoline amides using stable and readily available arylsulfonyl hydrazides has been developed. In the presence of 10 mol‐% Cu(OAc) 2 as a catalyst and Ag 2 CO 3 as an oxidant, a wide range of 8‐aminoquinoline amides underwent sulfonylation with arylsulfonyl hydrazides to generate structurally diverse aryl sulfones in moderate to good yields.