Premium
Base‐Free Palladium‐Catalyzed Hydrodechlorination of Aryl Chlorides with Pinacol Borane
Author(s) -
Yamamoto Yutaro,
Nogi Keisuke,
Yorimitsu Hideki,
Osuka Atsuhiro
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700189
Subject(s) - pinacol , borylation , borane , chemistry , aryl , palladium , catalysis , base (topology) , halide , medicinal chemistry , organic chemistry , polymer chemistry , mathematical analysis , alkyl , mathematics
Base‐free palladium‐catalyzed reactions of aryl chlorides with pinacol borane have been found to give the hydrodechlorinated products while similar reactions of aryl halides with pinacol borane in the presence of a base were reported to result in borylation. The base‐free conditions offer reasonable functional group compatibility. Experimental studies suggest that smooth and selective hydride transfer from pinacol borane to arylpalladium chloride under base‐free conditions is promoted by a strong interaction between the Lewis acidic boron and the chlorine on the palladium.