Premium
Synthesis of Rhodamine‐Based Chemosensor for Fe 3+ Selective Detection with off–on Mechanism and its Biological Application in DL‐Tumor Cells
Author(s) -
Kumar Ashish,
Kumari Chanda,
Sain Dibyendu,
Hira Sumit Kumar,
Manna Partha Pratim,
Dey Swapan
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700165
Subject(s) - rhodamine , fluorescence , hepes , chemistry , metal ions in aqueous solution , tumor cells , rhodamine b , ion , aqueous solution , photochemistry , nuclear chemistry , biochemistry , organic chemistry , cancer research , biology , physics , quantum mechanics , photocatalysis , catalysis
A novel rhodamine‐based chemosensor ( R1 ) has been designed and synthesised for identifying Fe 3+ ions among different metal ions in aqueous medium. The sensitivity test has been carried out by using UV‐vis and fluorescence methods taking μM concentration of R1 in HEPES buffer solution and the complexation has been described through fluorescence ‘off‐on’ mechanism. Metallation of R1 was found to be tolerant with respect to tumor cells proliferation and viability of human peripheral blood mononuclear cells and RBC. It has also been demonstrated that the significant uptake of the chemosensor by the tumor cells was observed in cell imaging analysis.