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Modified Sonogashira Coupling Strategy For the Functionalization of Substituted Quinoline
Author(s) -
Shaikh Mohammedumar M.,
Bhutiya Priyank L.,
Chikhalia Kishor H.
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700137
Subject(s) - sonogashira coupling , surface modification , quinoline , combinatorial chemistry , chemistry , pharmacophore , halogen , amine gas treating , organic chemistry , stereochemistry , palladium , catalysis , alkyl
Modified and efficient sonogashira coupling reaction tactic has been developed for the functionalization of quinoline motif at different position. Copper‐, amine‐ and ligand free synthetic strategy make this reaction more advance and beneficiary synthetic tool for the functionalization of quinoline pharmacophore than the previously reported. In dihaloquinoline, first halogen was blocked by employing nucleophilic substitution reaction with different heterocycles whereas remaining halogen was subjected for modified sonogashira synthetic strategy.