Di– tert– butyl N,N ‐diethylphosphoramidite as an Air Stable Ligand for Suzuki‐Miyaura and Buchwald‐Hartwig Reactions

We describe herein an air stable phosphorus ligand for both Suzuki‐Miyaura and Buchwald‐Hartwig palladium‐catalyzed cross coupling reactions. The versatility of the Pd(dba) 2 ‐di‐ tert ‐butyl N,N ‐diethylphosphoramidite catalytic system is demonstrated for a variety of aryl and heteroaryl halides. This ligand is ‘’bench stable’’ which allows easy catalyst preparation. Moreover, even at low catalyst loadings (0.5 %), excellent yields are usually achieved.