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Di– tert– butyl N,N ‐diethylphosphoramidite as an Air Stable Ligand for Suzuki‐Miyaura and Buchwald‐Hartwig Reactions
Author(s) -
Ilie Adriana,
Roiban GheorgheDoru,
Reetz Manfred T.
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700086
Subject(s) - catalysis , ligand (biochemistry) , halide , aryl , palladium , chemistry , aryl halide , combinatorial chemistry , medicinal chemistry , organic chemistry , polymer chemistry , biochemistry , alkyl , receptor
We describe herein an air stable phosphorus ligand for both Suzuki‐Miyaura and Buchwald‐Hartwig palladium‐catalyzed cross coupling reactions. The versatility of the Pd(dba) 2 ‐di‐ tert ‐butyl N,N ‐diethylphosphoramidite catalytic system is demonstrated for a variety of aryl and heteroaryl halides. This ligand is ‘’bench stable’’ which allows easy catalyst preparation. Moreover, even at low catalyst loadings (0.5 %), excellent yields are usually achieved.