Premium
Amberlite IRA 402(OH) Mediated Green Synthesis of Novel Benzothiazole–quinoline Conjugates as Cancer Theranostics
Author(s) -
Chhabra Mohit,
Babu Lavanya Thilak,
Mondal Ashaparna,
Sun Hongyan,
Paira Priyankar
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700066
Subject(s) - benzothiazole , quinoline , amberlite , chemistry , combinatorial chemistry , cytotoxicity , cancer cell , cancer cell lines , cancer , stereochemistry , in vitro , organic chemistry , biochemistry , medicine , adsorption
Abstract We have introduced Amberlite IRA 402(OH) mediated green synthesis of benzothiazolyl quinoline based fluorescent scaffolds ( 6a–l ) for cancer theranostic application. Compounds 6 b (8‐[2‐(2‐benzothiazol‐2‐yl‐phenoxy)‐ethoxy]‐5,7‐dibromoquinoline), 6 d (8‐[2‐(2‐benzothiazol‐2‐yl‐phenoxy)‐ethoxy]‐5‐chloro‐7‐iodoquinoline) and 6 g (8‐[2‐(2‐benzothiazol‐2‐yl‐phenoxy)‐propoxy]‐5‐chloroquinolin ‐e) demonstrated more or comparable cytotoxicity tocisplatin against all the tested cancer cell lines. Most of the synthesized compounds are 3–25 folds more selective in cancer cell line than normal fibroblast (MRC‐5 or HEK‐293). It was also evident that compound 6 a (8‐[2‐(2‐benzothiazol‐2‐yl‐phenoxy)‐ethoxy]‐quinoline) can be utilized as cancer theranostic agent since it has good quantum yield in water, significant cellular uptake, high potency and selectivity in all the cancer cell lines.