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Microwave‐Assisted Ligand‐Free Nickel‐Catalyzed β‐Boration of α,β‐Unsaturated Carbonyl Compounds with Bis(pinacolato)diboron
Author(s) -
Huang Xi,
Wang Mingming,
Wu Mengying,
Wang Jiayi,
Peng Yanqing,
Song Gonghua
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700057
Subject(s) - chemistry , hydroboration , ligand (biochemistry) , catalysis , microwave irradiation , nickel , medicinal chemistry , organic chemistry , biochemistry , receptor
Abstract A simple and efficient ligand‐free nickel‐based catalytic system has been developed for the β‐boration of α,β‐unsaturated carbonyl compounds with bis(pinacolato)diboron. With catalyst loading of 10–15 mol%, a series of β‐boration products from chalcones and cinnamates was obtained rapidly in moderate to excellent yields within 3–30 minutes under a nitrogen atmosphere and microwave irradiation. The combination of hydroboration with microwave irradiation provided a convenient and rapid method to afford a boronate group at the β‐position of carbonyl.