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A Mild, Convenient and Efficient Sodium Nitrite Mediated Hydrolysis of α‐Halo Ketones to Corresponding α‐Hydroxy Ketones
Author(s) -
Ghorpade Archana K.,
Akamanchi Krishnacharya G.
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700046
Subject(s) - chemistry , sodium nitrite , hydrolysis , dimethylformamide , nitrite , solvent , alkyl , ketone , organic chemistry , combinatorial chemistry , nitrate
A novel, concise and efficient method for conversion of α‐halo ketones into α‐hydroxy ketones using sodium nitrite in dimethylformamide(DMF) as solvent has been developed. This transformation is believed to proceed via in situ generation of alkyl nitrite intermediatesfollowed by hydrolysis to form α‐hydroxy ketones. The salient features of this protocol are mild reaction conditions, short reaction time and very good to excellent yields.