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Studies Towards the Synthesis of Stereoisomer of Acremolide B
Author(s) -
Yadav Jhillu S.,
Amrutapu Sravanth Kumar,
Pabbaraja Srihari
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201700007
Subject(s) - stereochemistry , chemistry
A convergent synthetic approach towards all carbon chain frame work of cyclicdepsipeptides acremolides A–D is described. The two key fragments, acyclic chain with four chiral centers and a dipeptide with two chiral centers were coupled together through an amide bond formation. Sharpless asymmetric epoxidation and Evans syn aldol reaction are the other key reactions involved in generating chiral centers.in the aliphatic side chain fragment.