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Novel and Efficient Synthesis of Benzimidazole and Benzthiazole Moieties Mediated by Triflic Anhydride and 2‐Nitropyridine
Author(s) -
Quadri Syed Aziz Imam,
Das Tonmoy C.,
Farooqui Mazahar
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201602049
Subject(s) - benzimidazole , chemistry , amide , intramolecular force , functional group , triflic acid , combinatorial chemistry , organic chemistry , catalysis , polymer
In the present report, inter and intramolecular C−N bond formation between the carbonyl carbon of urea or amide functional group with various amines mediated by triflic anhydride and 2‐nitropyridine is successfully investigated for the first time. The versatility of the method is demonstrated by exploring it on a wide range of substrates to synthesize diversified 2‐aminobenzimidazole, 2‐aminopyridoimidazole and 2‐substituted benzimidazole and benzthiazoles. Short reaction time, high yields and applicability in milder metal free reaction conditions are the highlights of the present methodology.