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Pressurized Hot Water Extraction as a Viable Bioprospecting Tool: Isolation of Coumarin Natural Products from Previously Unexamined Correa (Rutaceae) Species
Author(s) -
Deans Bianca J.,
Just Jeremy,
Chhetri Jamuna,
Burt Liam K.,
Smith James N.,
Kilah Nathan L.,
de Salas Miguel,
Gueven Nuri,
Bissember Alex C.,
Smith Jason A.
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201602006
Subject(s) - bioprospecting , rutaceae , coumarin , chemistry , hot water extraction , extraction (chemistry) , traditional medicine , biology , food science , botany , chromatography , medicine
The potential of a recently developed pressurized hot water extraction (PHWE) method employing an unmodified household espresso machine to facilitate rapid bioprospecting was investigated. A survey of some 16 Australian native plant species identified three Correa (Rutaceae) species containing significant quantities of coumarin natural products. As part of this study, seselin, (+)‐epoxysuberosin, alosin, (–)‐meranzin and heraclenin were isolated and, subsequently, used to synthesize the related natural products (+)‐trachypleuranin A and (–)‐yuehgesin B. In addition, seselin, (+)‐epoxysuberosin, alosin, and (–)‐meranzin were found to inhibit NQO1 activity. Interestingly, (–)‐meranzin showed inhibitory activity comparable to the known potent NQO1 inhibitor dicoumarol.