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Total Synthesis of Neuritogenic Alkynes: Lembehyne B and Key Intermediate of Lembehyne A
Author(s) -
D'yakonov Vladimir A.,
Makarov Alexey A.,
Dzhemileva Lilya U.,
Andreev PhD Evgeny N.,
Dzhemilev Usein M.
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601988
Subject(s) - total synthesis , stereoselectivity , chemistry , stereochemistry , key (lock) , combinatorial chemistry , organic chemistry , catalysis , computer science , operating system
A new Ti‐catalyzed cross‐cyclomagnesiation of aliphatic and oxygenated 1,2‐dienes with EtMgBr in the presence of Cp 2 TiCl 2 was used in the key stage for the development for the first time original methods for the preparation of racemic and natural neuritogenic alkynes lembehyne B and stereoselective syntheses of (4 Z ,8 Z )‐pentacosa‐4,8‐dien‐1‐ol ‐ the key intermediate in the total synthesis of lembehyne A.