Total Synthesis of Neuritogenic Alkynes: Lembehyne B and Key Intermediate of Lembehyne A | Zendy

D'yakonov Vladimir A. | Zendy; Makarov Alexey A. | Zendy; Dzhemileva Lilya U. | Zendy; Andreev PhD Evgeny N. | Zendy; Dzhemilev Usein M. | Zendy

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Total Synthesis of Neuritogenic Alkynes: Lembehyne B and Key Intermediate of Lembehyne A

Author(s) -

D'yakonov Vladimir A.,

Makarov Alexey A.,

Dzhemileva Lilya U.,

Andreev PhD Evgeny N.,

Dzhemilev Usein M.

Publication year - 2017

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201601988

Subject(s) - total synthesis , stereoselectivity , chemistry , stereochemistry , key (lock) , combinatorial chemistry , organic chemistry , catalysis , computer science , operating system

A new Ti‐catalyzed cross‐cyclomagnesiation of aliphatic and oxygenated 1,2‐dienes with EtMgBr in the presence of Cp 2 TiCl 2 was used in the key stage for the development for the first time original methods for the preparation of racemic and natural neuritogenic alkynes lembehyne B and stereoselective syntheses of (4 Z ,8 Z )‐pentacosa‐4,8‐dien‐1‐ol ‐ the key intermediate in the total synthesis of lembehyne A.

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