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Solvent‐, and Catalyst–free Acylation of Anilines with Meldrum's Acids: ANeat Access to Anilides
Author(s) -
Li JiangSheng,
Da YuDong,
Chen GuoQin,
Yang Qian,
Li ZhiWei,
Yang Fan,
Huang PengMian
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601965
Subject(s) - acylation , catalysis , chemistry , solvent , organic chemistry , combinatorial chemistry
An efficient and neat procedure for N ‐acylation of anilines has been developed using 5‐(un)substituted Meldrum's acids as acyl surrogates under neutral conditions in excellent yields. This protocol features a solvent‐free and catalyst‐free acylation process, and enables facile access to a vast array of structurally versatile sec ‐ and tert ‐anilides.
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