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Synthesis, Structural and Biological Studies of Some Half‐Sandwich d 6 ‐Metal Complexes with Pyrimidine‐Based Ligands
Author(s) -
Aradhyula Basava Punna Rao,
Kalidasan Mahesh,
Gangele Krishnakant,
Deb Debojit K.,
Shepherd Samanta L.,
Phillips Roger M.,
Poluri Krishna Mohan,
Kollipara Mohan Rao
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601926
Subject(s) - chemistry , denticity , metallacycle , ligand (biochemistry) , pyrimidine , metal , chelation , stereochemistry , cytotoxicity , medicinal chemistry , in vitro , x ray crystallography , organic chemistry , biochemistry , physics , receptor , optics , diffraction
The reaction of metal precursors {[Cp*MCl 2 ] 2 (M=Rh, Ir)} with 2‐aminopyrimidine ( L1 ) gave binuclear complexes as [(Cp*MCl 2 ) 2 (μ‐ L1 )], where L1 acted as a bridging ligand. While 2‐mercaptopyrimidine ( L2 ) with [Cp*MCl 2 ] 2 {M=Rh(III), Ir(III)} formed mononuclear di substituted complexes as [Cp*M( L2 ) 2 ], where L2 acted as a chelating as well as a monodentate ligand. The reaction of [CpRu(PPh 3 ) 2 Cl] with 2‐mercaptopyrimidine ( L2 ) led to the formation of mononuclear complex as general formula [CpRu(PPh 3 )( L2 )] in presence of a base. 2‐Mercaptopyrimidine ligand resulted complexes with strained four‐membered metallacycle while 2‐aminopyrimidine yielded bridged complexes. HOMO‐LUMO energy gaps and UV‐Visible bands were additionally rationalised by the DFT studies. The binding ability of the complexes to the CT‐DNA was confirmed using UV‐Visible and fluorescence spectroscopy. In vitro antibacterial activity of the complexes was evaluated against human pathogenic bacteria. Cytotoxicity of the complexes was examined by the MTT assay over three cancerous and one non‐cancer cell lines viz., BE, HT‐29, MIA−Pa‐Ca2 and ARPE‐19.