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Silver‐Mediated C−S Cross‐Coupling of Di(pyrimidin‐2‐yl) Disulfides with Aliphatic Carboxylic Acids
Author(s) -
Wang WenJuan,
Liu XiaoJun,
Wang Xi–Cun
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601870
Subject(s) - chemistry , alkyl , carboxylic acid , organic chemistry , coupling (piping) , medicinal chemistry , combinatorial chemistry , materials science , metallurgy
A silver‐mediated decarboxylative cross‐coupling of aliphatic carboxylic acids to deliver C−S couplings products is reported. This reaction occurs smoothly under mild conditions and tolerates a various 1,2‐di(pyrimidin‐2‐yl)disulfides and aliphatic carboxylic acids bearing both electron‐donating and electron‐withdrawing groups. It provides an alternative approach for the synthesis of alkyl pyrimidinyl sulfides, which may be applied as the key intermediates in the synthesis of drug candidates.