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Rhodium‐Catalyzed ortho ‐Selective C‐F Activation and Hydrodefluorination of Heterocycle‐Substituted Polyfluoroarenes: Dominated by Phosphine Ligands
Author(s) -
Chen Jianping,
Huang Dongyang,
Ding Yuqiang
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601839
Subject(s) - phosphine , chemistry , chemoselectivity , rhodium , hydride , ligand (biochemistry) , catalysis , combinatorial chemistry , organic chemistry , medicinal chemistry , metal , biochemistry , receptor
In this paper, the ortho ‐selective mono‐hydrodefluorination and/or di‐hydrodefluorination of heterocycle substituted polyfluoroarenes were catalyzed by rhodium complexes along with phosphine ligands and ethanol as hydride source. Diverse partially fluorinated aromatics had been synthesized by this method. The study of the mechanism demonstrated that ethanol was the sole hydride source in the cycle of hydrodefluorination. Furthermore, the phosphine ligand controlled chemoselectivity had been discussed by monitoring experiment.