Premium
A Facile Synthesis and Antituberculosis Properties of Almazole D and Its Enantiomer
Author(s) -
Lade Dhanaji M.,
Krishna Vagolu Siva,
Sriram Dharmarajan,
Rode Haridas B.
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601821
Subject(s) - enantiomer , oxazole , mycobacterium tuberculosis , combinatorial chemistry , chemistry , stereochemistry , tuberculosis , medicine , pathology
An efficient route for the synthesis of almazole D has been developed using oxidative cyclization as a key step. This approach is successfully applied to the first synthesis of almazole D enantiomer. ( R )‐almazole D and synthesized intermediates showed potent inhibition of Mycobacterium tuberculosis . This hybrid 5‐(3‐indolyl)oxazole scaffold has drug like properties and is a good starting point for further exploration in antituberculosis drug discovery.