A Facile Synthesis and Antituberculosis Properties of Almazole D and Its Enantiomer | Zendy

Lade Dhanaji M. | Zendy; Krishna Vagolu Siva | Zendy; Sriram Dharmarajan | Zendy; Rode Haridas B. | Zendy

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A Facile Synthesis and Antituberculosis Properties of Almazole D and Its Enantiomer

Author(s) -

Lade Dhanaji M.,

Krishna Vagolu Siva,

Sriram Dharmarajan,

Rode Haridas B.

Publication year - 2017

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201601821

Subject(s) - enantiomer , oxazole , mycobacterium tuberculosis , combinatorial chemistry , chemistry , stereochemistry , tuberculosis , medicine , pathology

An efficient route for the synthesis of almazole D has been developed using oxidative cyclization as a key step. This approach is successfully applied to the first synthesis of almazole D enantiomer. ( R )‐almazole D and synthesized intermediates showed potent inhibition of Mycobacterium tuberculosis . This hybrid 5‐(3‐indolyl)oxazole scaffold has drug like properties and is a good starting point for further exploration in antituberculosis drug discovery.

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