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Phosphate‐Mediated Enyne Synthesis from Allenols
Author(s) -
Asai Shota,
Kato Maho,
Monguchi Yasunari,
Sajiki Hironao,
Sawama Yoshinari
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601789
Subject(s) - enyne , chemistry , phosphate , activator (genetics) , sodium hydride , hydride , combinatorial chemistry , organic chemistry , catalysis , biochemistry , hydrogen , gene
An efficient synthetic pathway to enyne derivatives from readily‐available allenols has been accomplished using trimethyl phosphate as an inexpensive and stable activator of the hydroxy groups of the allenols in the presence of sodium hydride. The present method could be applied to various allenol derivatives to produce a variety of functionalized‐enyne products.