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I 2 ‐Catalyzed Total Synthesis of Collective 7‐Oxygenated Carbazole Alkaloids: Clauszoline‐K, ‐L, Clausine‐M, ‐N and Formal Synthesis of Siamenol
Author(s) -
Naykode Mahavir S.,
Tambe Shrikant D.,
Lokhande Pradeep D.
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601759
Subject(s) - carbazole , aromatization , ring (chemistry) , catalysis , chemistry , total synthesis , iodine , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry
A series of 7‐oxygenated carbazole alkaloids has been synthesized via Fischer‐Borsche ring and metal free condition. The key step encompasses the aromatization and one‐pot iodination process of Fischer‐Borsche ring using molecular iodine. The appropriately oxygenated functionality has been introduced to Fischer‐Borsche ring by our present method to synthesized Clauszoline‐K, ‐L, Clausine‐M, ‐N, Siamenol, Glycozolicine, and Clauraila.