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Synthesis of a Water‐Soluble Pyrazole Curcumin Derivative: In Vitro and In Vivo AGE Inhibitory Activity and Its Mechanism
Author(s) -
Sribalan Rajendran,
Shakambari Ganeshan,
Banuppriya Govindharasu,
Varalakshmi Perumal,
Subramanian Elayia Raja,
Sudhakar Sivasubramanium,
Padmini Vediappen
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601740
Subject(s) - curcumin , in vivo , pyrazole , in vitro , chemistry , derivative (finance) , pharmacology , stereochemistry , biochemistry , biology , microbiology and biotechnology , financial economics , economics
The new chemical entity, water‐soluble pyrazole curcumin derivative (PyCurOAc) was designed, synthesized and characterized for the purpose of inhibition of AGE formation. The compound showed an excellent in vitro AGEs inhibition activity than curcumin itself as well as the standard. Further, the AGE inhibition activity was substantiated in vivo using C.elegans as an animal model. The mechanistic investigation for the inhibition of AGEs with PyCurOAc was studied with glod‐4 expressions in C.elegans and glucose trapping method. This study suggests that the synthesized compound could be used to treat the formation of AGEs in hyperglycemic nematodes and higher animals.