Premium
Tri– tert ‐Butanolamine as an Organic Promoter in Nucleophilic Fluorination
Author(s) -
Shinde Sandip S.,
Khonde Nilesh S.,
Kumar Pradeep
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601735
Subject(s) - nucleophile , moiety , chemistry , alcohol , reactivity (psychology) , alkali metal , amine gas treating , alkene , ether , catalysis , halogenation , organic chemistry , medicinal chemistry , medicine , alternative medicine , pathology
Tri‐ tert ‐butanol amine acts as promoter with alkali metal salts in the nucleophilic fluorination of alkylsulfonates. It significantly enhances the reactivity of alkali metal salts with minimum formation of side‐products (alkene, ether, and alcohol) compared to other catalysts in fluorination reaction. The synergism of tert ‐alcohol and amine moiety plays a pivotal role in fluorination.