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A Three Component Synthesis of 2‐Aryl‐3‐imidamide Substituted 1,2‐Dihydroquinazolin‐4(1 H )‐ones
Author(s) -
Mandal Arkalekha,
Patel Bhisma K.
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601728
Subject(s) - pyrazine , aryl , component (thermodynamics) , chemistry , pyridine , combinatorial chemistry , position (finance) , product (mathematics) , organic chemistry , medicinal chemistry , stereochemistry , mathematics , alkyl , physics , geometry , finance , thermodynamics , economics
An efficient one‐pot three component synthesis of 2‐aryl‐3‐imidamide substituted 1,2‐dihydroquinazolin‐4( 1H )‐ones has been described herein using o ‐aminobenzhydrazide, 2‐pyridine/pyrazinecarbonitrile and arylaldehydes as the coupling partners. In the resultant product the 2‐position is substituted with various aromatic or heterocyclic groups and substituents at the 3‐position are picolinimidamide, 5‐phenylpicolinimidamide and pyrazine‐2‐carboximidamide groups, thus generating an array of compounds. The present synthetic protocol is greener and superior to the existing methods.