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A Quaternary Ammonium Salt Promoted Regioselective Iodination of Terminal Alkynes: A Convenient Access to 1‐Iodoalkynes in Aqueous Media
Author(s) -
Srujana Kodumuri,
Swamy Peraka,
Naresh Mameda,
Durgaiah Chevella,
Rammurthy Banothu,
Sai Gajula Krishna,
Sony Thokali,
Narender Nama
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601725
Subject(s) - reagent , regioselectivity , ammonium iodide , aqueous medium , halogenation , chemistry , environmentally friendly , ammonium , salt (chemistry) , aqueous solution , solvent , iodide , organic chemistry , iodine , combinatorial chemistry , catalysis , ecology , biology
A new protocol for the synthesis of 1‐iodoalkynes from terminal alkynes under metal‐free conditions in aqueous media via quaternary ammonium iodide and oxone mediated oxidative iodination has been developed. Simple reaction conditions, low cost and commercial availability of reagents and the use of readily available, non‐toxic and universal solvent i. e., water as a reaction media makes this approach as an eco‐friendly and economically viable.