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Antibacterial Nanoparticles Based on Fluorescent 3‐Substituted Uridine Analogue
Author(s) -
Reddy E. Ramanjaneya,
Yaseen Abdul M,
Rizvi Arshad,
Deora Girdhar S.,
Banerjee Sharmistha,
Sevilimedu Aarti,
Rajadurai Marina
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601708
Subject(s) - antimicrobial , fluorescence , combinatorial chemistry , chemistry , uridine , antibacterial activity , in vivo , bacteria , biophysics , nanoparticle , scaffold , nanotechnology , biochemistry , organic chemistry , materials science , biology , microbiology and biotechnology , rna , computer science , physics , genetics , quantum mechanics , gene , database
With a sudden and rapid increase in the spread of antimicrobial resistance, there is an urgent need for the development of novel antimicrobial therapies. Nanoparticles with antimicrobial activity provide advantages such as improved solubility, permeability, stability and selectivity. In this study, a uridine‐scaffold was connected to a pyrene fluorescent unit to obtain novel compound UPy via an economical and straightforward route. Further, fluorescent organic nanoparticles (FONs) were prepared via self assembly of UPy and were found to have antibacterial activity towards Gram positive bacteria. The fluorescent nature of the FONs allowed us to identify a binding partner and propose mechanism of action in vivo . We believe that UPy can be an excellent starting point for the development of novel, potent and selective antimicrobial nanotherapeutics.