Comprehensive Synthesis of Photoreactive Phenylthiourea Derivatives for the Photoaffinity Labeling | Zendy

Ishida Akiko | Zendy; Wang Lei | Zendy; Tachrim Zetryana Puteri | Zendy; Suzuki Takeyuki | Zendy; Sakihama Yasuko | Zendy; Hashidoko Yasuyuki | Zendy; Hashimoto Makoto | Zendy

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Comprehensive Synthesis of Photoreactive Phenylthiourea Derivatives for the Photoaffinity Labeling

Author(s) -

Ishida Akiko,

Wang Lei,

Tachrim Zetryana Puteri,

Suzuki Takeyuki,

Sakihama Yasuko,

Hashidoko Yasuyuki,

Hashimoto Makoto

Publication year - 2017

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201601675

Subject(s) - tyrosinase , photoaffinity labeling , chemistry , melanin , reagent , tyrosine , combinatorial chemistry , biochemistry , enzyme , organic chemistry , binding site

Phenylthiourea (PTU) is well known as bioactive compound and one of the reversible inhibitors for tyrosinase. Tyrosinase plays very important roles for tyrosine metabolisms to maintain the skin homeostasis from sunlight with forming melanin. Synthesis of photoaffinity label reagents of PTU will be attractive thesis to elucidate functional analysis for tyrosinase.

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