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Comprehensive Synthesis of Photoreactive Phenylthiourea Derivatives for the Photoaffinity Labeling
Author(s) -
Ishida Akiko,
Wang Lei,
Tachrim Zetryana Puteri,
Suzuki Takeyuki,
Sakihama Yasuko,
Hashidoko Yasuyuki,
Hashimoto Makoto
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601675
Subject(s) - tyrosinase , photoaffinity labeling , chemistry , melanin , reagent , tyrosine , combinatorial chemistry , biochemistry , enzyme , organic chemistry , binding site
Abstract Phenylthiourea (PTU) is well known as bioactive compound and one of the reversible inhibitors for tyrosinase. Tyrosinase plays very important roles for tyrosine metabolisms to maintain the skin homeostasis from sunlight with forming melanin. Synthesis of photoaffinity label reagents of PTU will be attractive thesis to elucidate functional analysis for tyrosinase.