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TBHP Promoted Cross‐Dehydrogenative coupling (CDC) Reaction: Metal/Additive‐Free Synthesis of Chromone‐Fused Quinolines
Author(s) -
Singh Jay B.,
Mishra Kalpana,
Gupta Tanu,
M.Singh Radhey
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601527
Subject(s) - chromone , chemistry , xanthone , coupling reaction , combinatorial chemistry , metal , medicinal chemistry , coupling (piping) , stereochemistry , organic chemistry , catalysis , materials science , metallurgy
A metal/additive‐free, TBHP‐promoted synthesis of 12 H ‐Chromeno[2,3‐ b ]quinolin‐12‐ones from 2‐phenoloxyquinolinyl‐3‐carboxaldehydes has been described via cross‐dehydrogenative coupling of aldehydic C−H bond with arene C−H bond in good to excellent yields. Reaction could be extended to the synthesis of Chromeno[2,3‐ c ]pyrazol‐4(1 H )‐ones, 3‐Phenyl‐5 H ‐chromeno[2,3‐ b ]pyridin‐5‐ones and Xanthone respectively.