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A Simple, Efficient Green Protocol for the Synthesis of β‐Enaminone and Enamino Ester Derivatives by Using Onion Extract as Green Catalyst
Author(s) -
Prabakaran Kaliyan,
Sivakumar Matam,
Perumal Muthu Seenivasa
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601515
Subject(s) - environmentally friendly , chemistry , catalysis , organic chemistry , methylene , ethanol , solvent , green chemistry , primary (astronomy) , reaction conditions , combinatorial chemistry , reaction mechanism , ecology , physics , astronomy , biology
We have developed an environmental friendly and highly efficient method for onion extract catalyzed enamination of 1,3‐dicarbonyl compounds and primary amines. This method is applicable to a wide range of aromatic/aliphatic/heterocyclic amines with active methylene compounds, and affords the β‐enaminone and enamino ester derivatives in good to excellent yields (up to 97 %) in an eco‐friendly solvent ethanol at room temperature. The use of onion extract makes the process environmentally benign.