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N‐Bromosuccinimide Promoted Direct Thiolation of Imidazoheteroaryl C‐H bonds with Disulfides
Author(s) -
Maddi Raghavender Reddy,
Shirsat Prashishkumar K.,
Kumar Santosh,
Meshram H. M.
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601460
Subject(s) - regioselectivity , chemistry , n bromosuccinimide , combinatorial chemistry , base (topology) , medicinal chemistry , organic chemistry , halogenation , catalysis , mathematics , mathematical analysis
A one‐pot protocol has been demonstrated for the regioselective sulfenylation of imidazoheterocycles with disulfides. In this method, thiols are converted to sulfenyl bromides and reacted with 2‐phenylimidazo [1, 2‐a] pyridines. This simple procedure is highly capable for sulfenylation with readily available starting materials in good to excellent yields under transition metal and base free conditions.