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Ultrasound‐Assisted Synthesis of Novel Pyrrole Dihydropyrimidinones in Lactic Acid
Author(s) -
Li YiHang,
Wang Lingting,
Wang Zhi,
Yuan Shuai,
Wu Shu,
Wang ShiFan
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601438
Subject(s) - thiourea , biginelli reaction , lactic acid , pyrrole , chemistry , urea , green chemistry , solvent , organic chemistry , condensation , nuclear chemistry , catalysis , reaction mechanism , bacteria , physics , thermodynamics , biology , genetics
An efficient and green method has been developed for the Biginelli reaction for the first time. Sixteen novel pyrrole dihydropyrimidinones were synthesized using ultrasound assisted one‐pot condensation of 1,3‐dicarbonyl compounds, aldehydes and urea/thiourea in lactic acid as green solvent. All of the compounds have been characterized by 1 H NMR, IR and ESI‐MS. Compared with the conventional Biginelli synthesis, the current progress strongly indicates that this sonochemical procedure is simple, safe, eco‐friendly and low‐cost synthetic approach for the synthesis of the pyrrole dihydropyrimidinone derivatives.