3‐Oxobutanamides in Heterocyclic Synthesis, Synthesis Approaches for new Pyridines, Pyrimidines and their Fused Derivatives | Zendy

Hussein Abdel Haleem M. | Zendy; ElAdasy AbuBakr A. | Zendy; Khames Ahmed A. | Zendy; Atalla Ahmed A. | Zendy; AbdelRady Mohamed | Zendy

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3‐Oxobutanamides in Heterocyclic Synthesis, Synthesis Approaches for new Pyridines, Pyrimidines and their Fused Derivatives

Author(s) -

Hussein Abdel Haleem M.,

ElAdasy AbuBakr A.,

Khames Ahmed A.,

Atalla Ahmed A.,

AbdelRady Mohamed

Publication year - 2017

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201601424

Subject(s) - malononitrile , yield (engineering) , chemistry , pyridine , derivative (finance) , reagent , ethyl cyanoacetate , condensation , nucleophile , condensation reaction , organic chemistry , medicinal chemistry , combinatorial chemistry , materials science , catalysis , physics , economics , financial economics , metallurgy , thermodynamics

Condensation of 3‐oxobutanamide derivative 1 with DMF‐DMA afforded the thiazolopyrimidines 4 , pyridine derivative 7 and naphthyridines 12 depending on the different reaction conditions. Condensation of 1 with triethylorthoformate afforded ethoxymethylene derivative 3 . The ethoxymethylenes 3 reacted with different nucleophilic reagents to yield 14 , 15 , 20 and 23–25 respectively. Also, it reacted with malononitrile and ethyl cyanoacetate to give pyridine derivatives 28 a,b . Finally, the ethoxymethylenes 3 reacted with β‐naphthol to yield the benzoquinoline derivative 34 .

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