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Cover Picture: DNA‐Decorated Luminescent Vesicles as Drug Carriers (ChemistrySelect 17/2016)
Author(s) -
Thelu Hari Veera Prasad,
Albert Shine K.,
Golla Murali,
Krishnan Nithiyanandan,
Yamijala Santosh Bhargav,
Nair Sreeja V.,
Srinivasula S. Murty,
Varghese Reji
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601420
Subject(s) - vesicle , nanocarriers , chemistry , drug delivery , dna , hela , stacking , biophysics , membrane , liposome , penetration (warfare) , nanotechnology , materials science , cell , organic chemistry , biochemistry , biology , operations research , engineering
This cover picture shows the cell penetration of drug loaded DNA based vesicle into HeLa cells. Vesicles are self‐assembled through the hydrophobic and π–π stacking interactions of chromophores, which constitute the membrane of the vesicle, whereas the hydrophilic DNA is exposed to the polar medium on either side of the membrane. The hydrophilic cavity of the vesicle allows the encapsulation of polar drug molecules, while nonpolar drugs can be encapsulated in the hydrophobic membrane. DNA‐directed surface addressability and unique drug encapsulation ability suggest that this kind of vesicles could be promising nanocarriers for drug delivery applications. More information can be found in the Full Paper by Srinivasula and Varghese et al. (DOI: 10.1002/slct.201600897) (Design: Mr. Alex Andrews P., IISER‐Thiruvananthapuram).