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A Concise Synthesis of (−)‐Incrustoporin and its Analogues by Pd–catalyzed Suzuki‐Miyaura Coupling from γ ‐Vinyl‐ γ ‐butyrolactone
Author(s) -
Nallasivam Jothi L.,
Fernandes Rodney A.
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601379
Subject(s) - combinatorial chemistry , aryl , coupling (piping) , chemistry , boronic acid , coupling reaction , catalysis , antifungal , organic chemistry , materials science , biology , alkyl , microbiology and biotechnology , metallurgy
A highly efficient synthesis of C3‐arylbutenolides by Suzuki‐Miyaura coupling is described. We developed a simple protocol to accomplish scaffolds of C3‐arylbutenolides which include antifungal agent (−)‐incrustoporin and twelve analogues by Pd‐catalyzed Suzuki‐Miyaura cross coupling reaction between chiral 3‐iodobutenolide and various aryl boronic acids under aerobic conditions in good to quantitative yields.