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Regioselective Synthesis of Pyrrolylpyrazole as a Multifunctional Compound: Potential Antibacterial as well as Anticancer Agent
Author(s) -
Divakar Mathiyazhagan Arun,
Shanmugam Sivakumar,
Muneeswaran Thillaichidambaram,
Ramakritinan Muthiah
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601332
Subject(s) - regioselectivity , combinatorial chemistry , chemistry , antibacterial activity , stereochemistry , aryl , pyrrole , antibacterial agent , organic chemistry , bacteria , antibiotics , biochemistry , biology , catalysis , alkyl , genetics
A regioselective synthesis of 3‐pyrazolyl‐4‐aryl substituted pyrrole derivatives from α ‐aroylidineketene dithioacetals using a convenient and efficient protocol. The pyrrolylpyrazole molecules were expected to have good application in biological system consequently most of the compounds shows excellent antibacterial activity when compared with streptomycin drug. All the synthesized compounds were studied for their anticancer activity in which 5 b , 5 e , 5 g , 5 i have cytotoxic potential on cervical cancer cells at lower concentration.