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One–pot Three–component Reaction of Barbituric acids, Aldehydes and 4‐Hydroxycoumarins: Synthesis of Some Novel Functionalized Furo[2,3‐ d ]pyrimidines
Author(s) -
Dutta Leema,
Bhuyan Pulak J.
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601320
Subject(s) - chemistry , barbituric acid , yield (engineering) , catalysis , ring (chemistry) , organic chemistry , dimethyl sulfoxide , component (thermodynamics) , iodine , intramolecular force , medicinal chemistry , condensation , materials science , physics , metallurgy , thermodynamics
Some novel functionalized furo[2,3‐ d ]pyrimidines were synthesized via one‐pot three‐component reaction of barbituric acids, aldehydes and 4‐hydroxycoumarins in the presence of iodine as catalyst in dimethyl sulfoxide (DMSO). The reaction involved in a condensation and Michael addition followed by lactone ring opening and intramolecular cyclization process to afford the product in high yield in easy work‐up procedure.