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Iodine–induced Oxidative Cyclisation of N ‐Acyl Amidines: A Rapid Synthesis of 3,5‐Disubstituted‐1,2,4‐Oxadiazoles
Author(s) -
Asad Mohammad,
Gupta Puneet K,
Jaiswal Subodh K,
Hajela Kanchan
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601194
Subject(s) - iodine , oxidative phosphorylation , chemistry , functional group , combinatorial chemistry , organic chemistry , biochemistry , polymer
A rapid and efficient metal‐free synthesis of 3,5‐disubstituted‐1,2,4‐oxadiazoles has been developed via iodine‐induced oxidative cyclisation of N ‐acyl amidines. This eco‐friendly approach allows wide functional group tolerance and results in the direct access of highly diversified 1,2,4‐oxadiazoles in 59–94 % yields.