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A Short Total Synthesis of the Antimalarial Flindersial Alkaloids
Author(s) -
Kaur Ramandeep,
Garg Yuvraj,
Pandey Satyendra Kumar
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601162
Subject(s) - annulation , regioselectivity , total synthesis , indole test , chemistry , intermolecular force , heck reaction , stereochemistry , combinatorial chemistry , antimalarial agent , organic chemistry , catalysis , plasmodium falciparum , molecule , palladium , biology , malaria , immunology
A short, efficient and novel approach for the syntheses of bis‐indole alkaloids flinderoles A−C, and desmethylflinderole C, is being described. The synthesis utilizes the optimized intermolecular Heck coupling and InCl 3 catalyzed stereo‐ and regioselective [3+2] annulation reactions as the key steps.