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Synthetic Studies toward the Revised Aglycone of Mandelalide A
Author(s) -
AnkiReddy Praveen,
AnkiReddy Sandeep,
Sabitha Gowravaram
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601076
Subject(s) - aglycone , epoxide , intramolecular force , chemistry , derivative (finance) , silylation , stereochemistry , combinatorial chemistry , catalysis , organic chemistry , glycoside , financial economics , economics
Synthesis of a silyl derivative of revised aglycone of marine anticancer macrolide Mandelalide A is described. The synthetic highlights include acid catalyzed epoxide opening, Chelation‐ controlled Grignard reaction, Still‐Gennari olefination, Pd‐catalyzed intramolecular alkoxycarbonylation, Kocien′ski‐Julia olefination and Shiina macrolactonization as keysteps.

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