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Extremely Small Iron Oxide Nanoparticles Stabilized with Catechol‐Functionalized Multidentate Block Copolymer for Enhanced MRI
Author(s) -
Li Puzhen,
Xiao Wangchuan,
Chevallier Pascale,
Biswas Depannita,
Ottenwaelder Xavier,
Fortin MarcAndré,
Oh Jung Kwon
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201601035
Subject(s) - catechol , copolymer , colloid , aqueous solution , denticity , nanoparticle , iron oxide , iron oxide nanoparticles , materials science , chemistry , peg ratio , chemical engineering , polymer chemistry , nuclear chemistry , polymer , nanotechnology , crystallography , crystal structure , organic chemistry , finance , engineering , economics
An effective mussel‐inspired multidentate block copolymer strategy having pendant anchoring catechol groups (Cat‐MDBC) to stabilize extremely small iron oxide nanoparticles (ESNPs) in water is reported. The resultant aqueous Cat‐MDBC/ESNP colloids with diameter ≈16 nm and core diameter ≈2 nm were non‐toxic to cells up to 200 μg/mL and exhibit excellent colloidal stability in physiological condition (pH=7) as well as in the presence of IgG model protein. More promisingly, they had the relaxivity ratio to be r 2 /r 1 =1.5, which is significantly lower than PEG‐coated SNPs with core diameter=1.5‐6 nm; further which is similar to those of Gd‐DOTA T 1 ‐weighted contrast agents. These results suggest that aqueous Cat‐MDBC/ESNP colloids could be a promising candidate for T 1 ‐weighted MRI contrast enhancement.
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