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Biodegradable Dendronized Polymers for Efficient mRNA Delivery
Author(s) -
Oldenhuis Nathan J.,
Eldredge Alexander C.,
Burts Alan O.,
Ryu Keun Ah,
Chung Jae,
Johnson Mark E.,
Guan Zhibin
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201600939
Subject(s) - messenger rna , immunotherapy , chemistry , polymer , dendritic cell , microbiology and biotechnology , nanotechnology , computational biology , biology , biochemistry , antigen , immune system , materials science , immunology , gene , organic chemistry
As chemically modified messenger RNAs become less immunogenic and more stable against RNases, the need for synthetic vectors that can efficiently deliver mRNA into cells has increased significantly. Based on a dendronized polypeptide (denpol) architecture, we describe here the development of a synthetic vector system for efficient delivery of mRNAs. The optimized denpols show high efficiency of mRNA delivery to a variety of cells including primary murine dendritic cells (BMDCs), giving it potential use for anti‐tumor immunotherapy.