Premium
One–pot Reaction for the Convenient Synthesis of Functionalized 2‐Oxaspiro[bicyclo[2.2.1]heptane‐2,3′‐indolines]
Author(s) -
Sun Jing,
Yang Mr. RenYin,
Yan ChaoGuo
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201600929
Subject(s) - malononitrile , triethylamine , bicyclic molecule , heptane , chemistry , phenacyl , indoline , cyanoacetamide , organic chemistry , ethanol , dabco , medicinal chemistry , octane , catalysis
An efficient synthetic protocol for functionalized 2‐oxaspiro[bicyclo[2.2.1]heptane‐2,3′‐indolines] was successfully developed by one‐pot two‐step reaction of phenacyl bromides, malononitrile and 3‐methyleneoxindolines in ethanol in the presence of triethylamine. On the other hand, the similar three‐component reaction of phenacyl bromides, ethyl cyanoacetate and 3‐methyleneoxindolines afforded functionalized spiro[cyclopentane‐1,3′‐indoline] derivatives.