An Efficient Four‐Component Approach for the Synthesis of Novel 5‐Methyl‐4‐(2‐(3‐methyl‐4‐nitroisoxazol‐5‐yl)‐ 1‐arylethyl)‐1H‐pyrazol‐3‐ol Derivatives and their Antibacterial Study | Zendy

Muthineni Narmada | Zendy; Satish Kumar Nandigama | Zendy; Chandrasekhara Rao L. | Zendy; Dileep Kumar V. | Zendy; Misra Sunil | Zendy; Raju Chowhan L. | Zendy; Meshram H. M. | Zendy

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An Efficient Four‐Component Approach for the Synthesis of Novel 5‐Methyl‐4‐(2‐(3‐methyl‐4‐nitroisoxazol‐5‐yl)‐ 1‐arylethyl)‐1H‐pyrazol‐3‐ol Derivatives and their Antibacterial Study

Author(s) -

Muthineni Narmada,

Satish Kumar Nandigama,

Chandrasekhara Rao L.,

Dileep Kumar V.,

Misra Sunil,

Raju Chowhan L.,

Meshram H. M.

Publication year - 2016

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201600915

Subject(s) - isoxazole , ethyl acetoacetate , hydrazine (antidepressant) , chemistry , yield (engineering) , aldehyde , hydrate , component (thermodynamics) , piperidine , medicinal chemistry , organic chemistry , catalysis , materials science , physics , thermodynamics , chromatography , metallurgy

A One pot four‐component domino reactions were developed for the synthesis of 5‐methyl‐4‐(2‐(3‐methyl‐4‐nitroisoxazol‐5‐yl)‐1‐arylethyl)‐1H‐pyrazol‐3‐ols derivatives in excellent yield from hydrazine hydrate ( 1 ), ethyl acetoacetate ( 2 ), aldehyde ( 3 ) and 3,5‐dimethyl‐4‐nitro‐isoxazole ( 4 ) using 10 mol% of piperidine. This method is simple, efficient and multiple bonds were generated (two C−C, one C−N, one O−H and one C=N) in a single step. These novel 5‐methyl‐4‐(2‐(3‐methyl‐4‐nitroisoxazol‐5‐yl)‐1‐arylethyl)‐1H‐pyrazol‐3‐ol derivatives are evaluated as anti‐bacterial agents.

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