Premium
An Efficient Four‐Component Approach for the Synthesis of Novel 5‐Methyl‐4‐(2‐(3‐methyl‐4‐nitroisoxazol‐5‐yl)‐ 1‐arylethyl)‐1H‐pyrazol‐3‐ol Derivatives and their Antibacterial Study
Author(s) -
Muthineni Narmada,
Satish Kumar Nandigama,
Chandrasekhara Rao L.,
Dileep Kumar V.,
Misra Sunil,
Raju Chowhan L.,
Meshram H. M.
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201600915
Subject(s) - isoxazole , ethyl acetoacetate , hydrazine (antidepressant) , chemistry , yield (engineering) , aldehyde , hydrate , component (thermodynamics) , piperidine , medicinal chemistry , organic chemistry , catalysis , materials science , physics , thermodynamics , chromatography , metallurgy
A One pot four‐component domino reactions were developed for the synthesis of 5‐methyl‐4‐(2‐(3‐methyl‐4‐nitroisoxazol‐5‐yl)‐1‐arylethyl)‐1H‐pyrazol‐3‐ols derivatives in excellent yield from hydrazine hydrate ( 1 ), ethyl acetoacetate ( 2 ), aldehyde ( 3 ) and 3,5‐dimethyl‐4‐nitro‐isoxazole ( 4 ) using 10 mol% of piperidine. This method is simple, efficient and multiple bonds were generated (two C−C, one C−N, one O−H and one C=N) in a single step. These novel 5‐methyl‐4‐(2‐(3‐methyl‐4‐nitroisoxazol‐5‐yl)‐1‐arylethyl)‐1H‐pyrazol‐3‐ol derivatives are evaluated as anti‐bacterial agents.