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Three‐Component Synthesis of 3‐Aminoalkylindoles using Iron(III) Phosphate
Author(s) -
Aghaalikhani Soheyla,
Behbahani Farahnaz K.
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201600901
Subject(s) - aniline , catalysis , aldehyde , indole test , chemistry , component (thermodynamics) , combinatorial chemistry , organic chemistry , phosphate , physics , thermodynamics
Catalytic synthesis of 3‐substituted indole derivatives by a one‐pot three‐component coupling reaction between aldehyde, N ‐methyl aniline and indole in the presence of FePO 4 is described. Aldehydes having both electron‐donating and electron‐withdrawing groups were used and resulted the desired products in high yields Simple procedure, easy work up and employing of reusable and green catalyst are advantages of this protocol.