Premium
DNA‐Decorated Luminescent Vesicles as Drug Carriers
Author(s) -
Thelu Hari Veera Prasad,
Albert Shine K.,
Golla Murali,
Krishnan Nithiyanandan,
Yamijala Santosh Bhargav,
Nair Sreeja V.,
Srinivasula S. Murty,
Varghese Reji
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201600897
Subject(s) - nanocarriers , vesicle , amphiphile , dna , drug delivery , hela , nanotechnology , biophysics , biocompatibility , liposome , chemistry , drug carrier , membrane , materials science , cell , copolymer , biochemistry , biology , organic chemistry , polymer
DNA based spherical nanostructures is one of the promising nanocarriers for drug delivery applications because of their excellent biocompatibility and unique structural features of DNA. Herein, we report the amphiphilicity driven self‐assembly of DNA‐phenyleneethynylene based amphiphile into luminescent vesicles and their cellular uptake toward HeLa cell. Spectroscopic and microscopic analyses reveal the self‐assembly of this class of amphiphiles into vesicular nanostructures with corona made of DNA and a functional hydrophobic membrane. Vesicles exhibit promising cell permeability.