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Mn(III)‐Salen Protect Against Different ROS Species Generated by the Aβ16‐Cu Complex
Author(s) -
Walke Gulshan R.,
Ranade Dnyanesh S.,
Bapat Archika M.,
Srikanth Rapole,
Kulkarni Prasad P.
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201600808
Subject(s) - chemistry , reactive oxygen species , redox , oxidative stress , catalysis , metal salen complexes , mass spectrometry , medicinal chemistry , inorganic chemistry , biochemistry , chromatography
Aβ‐Cu complex generates different reactive oxygen species (ROS) which are responsible for oxidative stress in neuronal cells. We studied the effect of Mn(III)‐salen on Aβ‐Cu catalyzed ROS generation using different assays. Mn(III)‐salen reacts with O 2 •− generated by Aβ‐Cu and delay H 2 O 2 production. Mn(III)‐salen significantly inhibits the formation of HO • generated by Aβ‐Cu which is further confirmed using mass spectrometry analysis. Our results indicate that H 2 O 2 generated by Aβ‐Cu activates Mn(III)‐salen to oxomanganese which in turn detoxify Aβ‐Cu‐induced NO production in microglial cells. Overall, Mn(III)‐salen complex can efficiently inhibits different ROS generated by Aβ‐Cu due to its redox flexibility.