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Pyrrolo[2,3‐ b ]pyridine Derivatives: Synthesis and Preliminary Evaluation of their Calf Thymus DNA Binding Properties
Author(s) -
Singla Prinka,
Luxami Vijay,
Paul Kamaldeep
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201600801
Subject(s) - imidazopyridine , chemistry , pyridine , benzimidazole , acylation , benzothiazole , iodide , dna , stereochemistry , fluorescence , halide , alkylation , medicinal chemistry , combinatorial chemistry , organic chemistry , catalysis , biochemistry , physics , quantum mechanics
Benzothiazole, benzimidazole and imidazopyridine promoted substitutions at C3 position of 1 H ‐pyrrolo[2,3‐ b ]pyridine have been reported. A new series of acylation as well as monoalkylation and dialkylation of 1 H ‐pyrrolo[2,3‐ b ]pyridine with different acyl and alkyl halides has been synthesized in moderate to good yields. Palladium catalyzed Suzuki‐Miyaura cross‐coupling has also been approached for the arylation at C6 position of imidazopyridine. Further, interaction studies of these compounds have been performed with calf thymus‐DNA using UV‐visible and fluorescence spectroscopic techniques. The effect of ionic strength and iodide, determined by absorption and emission spectra, supported the binding of compounds with ct‐DNA.