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A Practicable Synthesis of Oxazol‐5(4 H )‐ones Through Hydrogenation: Scope and Applications
Author(s) -
Pinheiro Danielle L. J.,
Ávila Eloah P.,
Amarante Giovanni W.
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201600639
Subject(s) - scope (computer science) , stereoselectivity , ring (chemistry) , combinatorial chemistry , catalysis , chemistry , catalytic hydrogenation , organic chemistry , reaction conditions , transformation (genetics) , organocatalysis , computer science , enantioselective synthesis , biochemistry , gene , programming language
A practicable hydrogenation of arylidene oxazolones is presented. Catalytic heterogeneous Pd/C shows to be effective system for this transformation, with no need of any extra additive. The hydrogenated products were isolated in good to high yields. Besides, this reaction condition allows us to combine organocatalytic processes and perform one‐pot stereoselective Michael‐type, Mannich‐type and ring‐opening reactions. The final products were isolated in moderate to good yields and with up to > 20:1 dr .