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Synthesis of Indole Annulated [1,3]‐Thiazaheterocycles and ‐macrocycles via Ring‐Closing Metathesis
Author(s) -
Muthusamy Sengodagounder,
Kumar Muniyappankovilthottam Devaraj Senthil,
Suresh Eringathodi
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201600583
Subject(s) - ring closing metathesis , metathesis , tricyclic , oxindole , indole test , ring (chemistry) , chemistry , stereochemistry , combinatorial chemistry , salt metathesis reaction , catalysis , organic chemistry , polymerization , polymer
The diversity‐oriented organic synthesis of novel indole annulated tricyclic [1,3]‐thiazepino, thiazocino, thiazonino, thiazecino, thiazacycloundecino scaffolds with Z ‐selective and the symmetrical pentacyclic thiazaindole macrocyclic derivatives was demonstrated from 2‐oxindole via ring‐closing metathesis reaction as the key step in the presence of Grubbs’ catalyst and Lewis acid as an additive. This synthetic strategy provides an efficient way to access a library of novel tricyclic thiazaheterocycles and pentacyclic thiazamacrocycles.