Premium
Palladium‐Catalyzed Hydroxycarbonylation of Aryl Halides with the in‐situ Generation of CO and H 2 O
Author(s) -
Li ChongLiang,
Qi Xinxin,
Wu XiaoFeng
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201600514
Subject(s) - halide , acetic anhydride , palladium , catalysis , aryl , formic acid , chemistry , acetic acid , benzoic acid , in situ , alcohol , organic chemistry , medicinal chemistry , alkyl
An interesting palladium‐catalyzed hydroxycarbonylation of aryl halides with the in‐situ generation of CO and H 2 O has been developed. CO was in‐situ generated from formic acid with acetic anhydride as the activator and H 2 O was in‐situ generated from acetic acid and alcohol esterification. A variety of benzoic acid derivatives were produced in moderate to good yields from the corresponding aryl halides. No additional water addition is required during the whole process.