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Total Synthesis of Antifungal Macrolide Sch 725674
Author(s) -
Reddy Yugendar,
Sabitha Gowravaram
Publication year - 2016
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201600512
Subject(s) - total synthesis , antifungal , ring (chemistry) , chemistry , stereochemistry , propargyl , alcohol , propargyl alcohol , organic chemistry , biology , microbiology and biotechnology , catalysis
Total synthesis of the 14‐membered macrolide Sch 725674 has been developed that is based on macrocyclic ring closure either by Yamaguchi or Shiina macrolactonization and the construction of the precursor seco acid by Pd(OH) 2 transformation of primary propargyl alcohol/HWE olefination between two fragments is shown.